No, but if you have a drain or access to clean-outs, access should be maintained, not restricted. Be sure to check with your local authority for building code recommendations before covering any basement floor drain or clean-out access.
It is not a requirement to install a basement drain prior to installing DRICORE® Subfloor. If you install DRICORE® Subfloor panels over the drain access, cut an access opening in the panel that rests over top of the drain and install a decorative floor drain cover over top of your finished flooring.